ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

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Chemical Name:ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate
CAS No.:1403680-09-0
Molecular Formula:C₁₈H₁₄ClF₃N₄O₂
Molecular Weight:410.783
Hs Code.:

Synonyms:ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

There total 4 articles about ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1403680-09-0
ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / ethanol / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: acetic acid; hydrogen bromide / dichloromethane / 0 - 20 °C

3.1: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene; water / 5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydrogen bromide; sodium; sodium carbonate; acetic acid; lithium chloride; In ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.06.025

Reference yield:

: 951784-50-2
ethyl 4-(2-aminopyrimidin-4-yl)-2-cyano-4-oxobutanoate

: 1403680-09-0
ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; hydrogen bromide / dichloromethane / 0 - 20 °C

2: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene; water / 5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydrogen bromide; sodium carbonate; acetic acid; lithium chloride; In ethanol; dichloromethane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.06.025

Reference yield:

: 106157-91-9,845267-58-5
1-(2-amino-pyrimidin-4-yl)-2-bromo-ethanone hydrobromide

: 1403680-09-0
ethyl 5-(2-aminopyrimidin-4-yl)-2-[5-chloro-2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / ethanol / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: acetic acid; hydrogen bromide / dichloromethane / 0 - 20 °C

3.1: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene; water / 5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydrogen bromide; sodium; sodium carbonate; acetic acid; lithium chloride; In ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.06.025