methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Base Information

• Chemical Name: methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• CAS No.: 868636-02-6
• Molecular Formula: C₁₇H₁₆N₂O₄
• Molecular Weight: 312.325
• Mol file: 868636-02-6.mol

Synonyms:methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Chemical Property of methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

There total 3 articles about methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

dimethyl sulfate (77-78-1) + 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (600179-44-0) → methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (868636-02-6)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1002/jhet.5570420629

Reference yield:

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (67123-97-1) → methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (868636-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / potassium carbonate / dimethylsulfoxide / 4 h / 100 °C

2: 52 percent / potassium carbonate / acetone / 2 h / Heating

With potassium carbonate; In dimethyl sulfoxide; acetone;

DOI:10.1002/jhet.5570420629

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → methyl 2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (868636-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / potassium carbonate / dimethylsulfoxide / 4 h / 100 °C

2: 52 percent / potassium carbonate / acetone / 2 h / Heating

With potassium carbonate; In dimethyl sulfoxide; acetone;

DOI:10.1002/jhet.5570420629

upstream raw materials:

dimethyl sulfate

2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

ortho-nitrofluorobenzene

Downstream raw materials:

3-hydroxymethyl-2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline