(Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride

Base Information

Chemical Name:(Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride
CAS No.:1048962-49-7
Molecular Formula:C₅H₉NO*ClH
Molecular Weight:135.594
Hs Code.:
Mol file:1048962-49-7.mol

Synonyms:meso-(1R,5S,6R)-3-oxabicyclo[3.1.0]Hexan-6-endoamine hydrochloride

Suppliers and Price of (Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1α,?5α,?6α)?-3-?Oxabicyclo[3.1.0]?hexan-?6-?amineHydrochloride
10mg
$ 70.00

Chemenu
(1R,5S,6r)-bicyclo[3.1.0]hexan-6-aminehydrochloride 95%
1g
$ 912.00

American Custom Chemicals Corporation
TRANS-6-AMINO-3-OXABICYCLO[3.1.0]HEXANE HYDROCHLORIDE 95.00%
5MG
$ 457.70

Total 6 raw suppliers

Chemical Property of (Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

(1α,?5α,?6α)?-3-?Oxabicyclo[3.1.0]?hexan-?6-?amineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (1α,?5α,?6α)?-3-?Oxabicyclo[3.1.0]?hexan-?6-?amine Hydrochloride is an intermediate in preparation of piperidinyl and piperazinyl pyrazolylpyridinylmethanone antiviral agents.

Technology Process of (Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride

There total 4 articles about (Meso-1R,5S,6r)-3-Oxabicyclo[3.1.0]Hexan-6-endo-Amine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: tert-butyl (1R,5S,6R)-3-oxabicyclo[3.1.0]hexan-6-ylcarbamate

: 1048962-49-7,693248-55-4
meso-(1R,5S,6R)-3-oxabicyclo[3.1.0]Hexan-6-endoamine hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02156

Reference yield: 93.0%

: benzyl (1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-ylcarbamate

: 1048962-49-7,693248-55-4
meso-(1R,5S,6R)-3-oxabicyclo[3.1.0]Hexan-6-endoamine hydrochloride

Guidance literature:: benzyl (1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-ylcarbamate; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 81056-11-3
(1R,5S,6R)-ethyl 3-oxabicyclo[3.1.0]hexane-6-carboxylate

: 1048962-49-7,693248-55-4
meso-(1R,5S,6R)-3-oxabicyclo[3.1.0]Hexan-6-endoamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water; methanol / 3 h / 20 °C

2: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 20 °C / Reflux

3: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

With diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; water; toluene;