Technology Process of 5-deaza-5,6,7,8-tetrahydroisofolic acid
There total 9 articles about 5-deaza-5,6,7,8-tetrahydroisofolic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; trifluoroacetic acid;
platinum(IV) oxide;
at 25 ℃;
for 18h;
under 2327.2 - 2844.3 Torr;
DOI:10.1021/jm00106a021
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 13 percent / H2, AcOH-H2O / Raney Ni / 18 h / 2844.3 Torr / Ambient temperature
2: 68.6 percent / 1 N NaOH / methanol / 1.) RT, 48 h, 2.) 45 - 50 deg C, 2 h
3: 68 percent / CF3COOH, H2 / PtO2 / 18 h / 25 °C / 2327.2 - 2844.3 Torr
With
sodium hydroxide; hydrogen; acetic acid; trifluoroacetic acid;
platinum(IV) oxide; nickel;
In
methanol;
DOI:10.1021/jm00106a021
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / H2 / 10percent Pd/C / dimethylformamide; 2-methoxy-ethanol / 0.5 h / 2896.03 Torr
2: 13 percent / H2, AcOH-H2O / Raney Ni / 18 h / 2844.3 Torr / Ambient temperature
3: 68.6 percent / 1 N NaOH / methanol / 1.) RT, 48 h, 2.) 45 - 50 deg C, 2 h
4: 68 percent / CF3COOH, H2 / PtO2 / 18 h / 25 °C / 2327.2 - 2844.3 Torr
With
sodium hydroxide; hydrogen; acetic acid; trifluoroacetic acid;
platinum(IV) oxide; palladium on activated charcoal; nickel;
In
methanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a021
