(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Base Information

Chemical Name:(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester
CAS No.:1027646-67-8
Molecular Formula:C₃₀H₄₀O₃Si
Molecular Weight:476.731
Hs Code.:

Synonyms:(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Suppliers and Price of (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

There total 8 articles about (E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78629-21-7
(E)-6,6-dimethyl-2-hepten-4-ynyl bromide

: 180071-79-8
ethyl-3-<((2-methylphenyl)dimethylsilyl)methoxy>propinoate

: 1027646-67-8
(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -70 deg C, 1 h, 2.) hexamethylphosphorotriamide, -70 deg C -> r.t.;
DOI:10.1080/00397919608005229

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1027646-67-8
(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / triethylamine, Pd(OAc)2, tris(o-tolyl)phosphine / 100 °C

2: 1.) K₂CO₃, 2.) KI / 1.) DMSO, 90 deg C, 30 min, 2.) DMSO, 90 deg C, 5 h

3: 90 percent / H₂ / Pd/C / methanol / 10 h / Ambient temperature

4: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 1 h, 2.) hexamethylphosphorotriamide, -70 deg C -> r.t.

With palladium diacetate; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; lithium diisopropyl amide; palladium on activated charcoal; In methanol;
DOI:10.1080/00397919608005229

Reference yield:

: 591-20-8
3-Bromophenol

: 1027646-67-8
(E)-2-{3-[(Dimethyl-o-tolyl-silanyl)-methoxy]-benzyl}-8,8-dimethyl-non-4-en-6-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / triethylamine, Pd(OAc)2, tris(o-tolyl)phosphine / 100 °C

2: 1.) K₂CO₃, 2.) KI / 1.) DMSO, 90 deg C, 30 min, 2.) DMSO, 90 deg C, 5 h

3: 90 percent / H₂ / Pd/C / methanol / 10 h / Ambient temperature

4: 1.) lithium diisopropylamide / 1.) THF, -70 deg C, 1 h, 2.) hexamethylphosphorotriamide, -70 deg C -> r.t.

With palladium diacetate; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; lithium diisopropyl amide; palladium on activated charcoal; In methanol;
DOI:10.1080/00397919608005229