Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

Base Information

Chemical Name:Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide
CAS No.:1414967-04-6
Molecular Formula:C₂₁H₂₉N₃O₅S
Molecular Weight:435.544
Hs Code.:

Synonyms:Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

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Chemical Property of Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

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Technology Process of Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

There total 7 articles about Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1414968-10-7
tetrahydro-pyran-4-carboxylic acid [4-(4-amino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

: 814-68-6,25189-84-8
acryloyl chloride

: 1414967-04-6
Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1414968-09-4
(1-{4-[Methyl-(tetrahydro-pyran-4-carbonyl)-amino]-benzenesulfonyl}-piperidin-4-yl)-carbamic acid tert-butyl ester

: 1414967-04-6
Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1414968-08-3
[1-(4-Methylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

: 1414967-04-6
Tetrahydro-pyran-4-carboxylic acid [4-(4-acryloylamino-piperidine-1-sulfonyl)-phenyl]-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;