4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

Base Information

Chemical Name:4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate
CAS No.:1311269-14-3
Molecular Formula:C₃₇H₃₆N₆O₅S
Molecular Weight:676.796
Hs Code.:

4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

Synonyms:4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

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Chemical Property of 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

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Technology Process of 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

There total 7 articles about 4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1311269-32-5
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 3173-56-6
benzyl isothiocyanate

: 1311269-14-3
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-30-3
(3R)-3-[(4-hydroxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 1311269-14-3
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

2.2: 20 °C / Iknert atmosphere

3.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With pyridine; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; toluene;
DOI:10.1002/anie.201101210

Reference yield:

: 1311269-28-9
(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile

: 1311269-14-3
4-{[(3R)-7-cyano-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl-N-benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 - 30 °C / Inert atmosphere

1.2: 20 °C / Iknert atmosphere

2.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; toluene;
DOI:10.1002/anie.201101210