3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

Base Information

Chemical Name:3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid
CAS No.:1234842-32-0
Molecular Formula:C₂₁H₂₂FNO₄
Molecular Weight:371.408
Hs Code.:

Synonyms:3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

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Chemical Property of 3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

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Technology Process of 3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

There total 5 articles about 3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1234848-28-2
ethyl 3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoate

: 1234842-32-0
3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

Guidance literature:: ethyl 3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1234842-32-0
3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 24 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

4.2: 20 °C

With water; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 53618-29-4,119870-80-3,65480-44-6
(E)-ethyl 2-methyl-3-(4-nitrophenyl)acrylate

: 1234842-32-0
3-(4-(5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamido)phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

2.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

3.2: 20 °C

With water; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;