3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

Base Information

Chemical Name:3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol
CAS No.:442521-56-4
Molecular Formula:C₂₀H₃₅NO₂
Molecular Weight:321.503
Hs Code.:

Synonyms:3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

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Chemical Property of 3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

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Technology Process of 3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

There total 11 articles about 3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: acetic acid 1-acetoxymethyl-2-(2-methylamino-4,5-dipentyl-phenyl)-ethyl ester

: 442521-56-4
3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(02)00099-6

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 442521-56-4
3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 11 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 87.6 percent / tetrahydrofuran / 24 h / 40 °C

2.1: 73.5 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 96.8 percent / pyridine / 0.5 h / 20 °C

4.1: 100 percent / PdCl₂(PPh₃)2; Et₃N; CuI / tetrahydrofuran / 18 h / 20 °C

5.1: 77.3 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C / 760 Torr

6.1: 85.8 percent / benzyltrimethylammonium dichloroiodate; CaCO₃ / CH₂Cl₂ / 2.5 h / 20 °C

7.1: Ac₂O / 2 h / 50 °C

7.2: 90 percent / tetrahydrofuran / 0.5 h / 0 °C

8.1: 68.2 percent / PdCl₂(PPh₃)2; Et₃N; CuI / tetrahydrofuran / 44 h / 20 °C

9.1: 77.3 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

10.1: BH₃ / tetrahydrofuran / 1 h / 0 °C

11.1: 910 mg / aq. NaOH / methanol / 0.33 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; lithium borohydride; borane; hydrogen; acetic anhydride; sodium hydride; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 4.1: Sonogashira coupling / 8.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)00099-6

Reference yield:

: 442521-40-6
ethyl 3-(4-bromo-2-nitrophenyl)-2-oxopropanoate

: 442521-56-4
3-(2-methylamino-4,5-dipentyl-phenyl)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 73.5 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

2.1: 96.8 percent / pyridine / 0.5 h / 20 °C

3.1: 100 percent / PdCl₂(PPh₃)2; Et₃N; CuI / tetrahydrofuran / 18 h / 20 °C

4.1: 77.3 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C / 760 Torr

5.1: 85.8 percent / benzyltrimethylammonium dichloroiodate; CaCO₃ / CH₂Cl₂ / 2.5 h / 20 °C

6.1: Ac₂O / 2 h / 50 °C

6.2: 90 percent / tetrahydrofuran / 0.5 h / 0 °C

7.1: 68.2 percent / PdCl₂(PPh₃)2; Et₃N; CuI / tetrahydrofuran / 44 h / 20 °C

8.1: 77.3 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

9.1: BH₃ / tetrahydrofuran / 1 h / 0 °C

10.1: 910 mg / aq. NaOH / methanol / 0.33 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; lithium borohydride; borane; hydrogen; acetic anhydride; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; calcium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3.1: Sonogashira coupling / 7.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)00099-6