(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

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Chemical Name:(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide
CAS No.:848852-36-8
Molecular Formula:C₂₃H₂₆F₃N₃O₅Si
Molecular Weight:509.557
Hs Code.:

Synonyms:(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

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Chemical Property of (E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

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Technology Process of (E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

There total 7 articles about (E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 848851-55-8
C⁽⁵⁸⁰⁾H₄₈₆₀

: 1066-54-2
trimethylsilylacetylene

: 848852-36-8
(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.01.062

Reference yield:

: 848852-32-4
2,3,4-trifluoro-5-vinylbenzoic acid

: 848852-36-8
(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

2: sodium periodate; osmium(VIII) oxide; sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one / tetrahydrofuran

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; copper(l) iodide; osmium(VIII) oxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2011.01.062

Reference yield:

: 848852-33-5
3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-vinylbenzoic acid

: 848852-36-8
(E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate; osmium(VIII) oxide; sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one / tetrahydrofuran

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran

With bis-triphenylphosphine-palladium(II) chloride; sodium periodate; copper(l) iodide; osmium(VIII) oxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2011.01.062