(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

Base Information

Chemical Name:(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate
CAS No.:1609172-09-9
Molecular Formula:C₂₀H₂₂N₂O₄S
Molecular Weight:386.472
Hs Code.:

Synonyms:(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

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Chemical Property of (E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

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Technology Process of (E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

There total 3 articles about (E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1609172-05-5
1-(3-bromophenylsulfonyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

: 1609172-09-9
(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: With palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm401899x

Reference yield:

: 2905-24-0
3-Bromobenzenesulfonyl chloride

: 1609172-09-9
(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / Reflux

2: triethylamine; triphenylphosphine; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With pyridine; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm401899x

Reference yield:

: 10592-27-5
7-azaindoline

: 1609172-09-9
(E)-tert-butyl 3-(3-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / Reflux

2: triethylamine; triphenylphosphine; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With pyridine; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm401899x