N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide
CAS No.:1307272-97-4
Molecular Formula:C₂₀H₂₂ClFN₄O₃S₂
Molecular Weight:485.003
Hs Code.:

Synonyms:N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

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Chemical Property of N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

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Technology Process of N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

There total 4 articles about N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.9%

: 10147-36-1
n-propanesulfonyl chloride

: 1331843-25-4
2-(4-(3-amino-2-fluorophenyl)-5-(2-chloropyrimidin-4-yl)thiazol-2-yl)-2-methylpropan-1-ol

: 1307272-97-4
N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1195769-52-8
2-propen-1-yl {3-[bromo(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}carbamate

: 1307272-97-4
N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ISOPROPYLAMIDE / 2 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride; acetic acid / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 4 h / 40 °C / Inert atmosphere

3: pyridine / 2 h / 20 °C / Inert atmosphere

With pyridine; tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 1195769-50-6
3-hydroxy-2,2-dimethylpropanethioamide

: 1307272-97-4
N-(3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)-2-fluorophenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ISOPROPYLAMIDE / 2 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride; acetic acid / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 4 h / 40 °C / Inert atmosphere

3: pyridine / 2 h / 20 °C / Inert atmosphere

With pyridine; tri-n-butyl-tin hydride; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; ISOPROPYLAMIDE;