(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

Base Information

Chemical Name:(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate
CAS No.:1404473-96-6
Molecular Formula:C₂₉H₃₀BrN₆O₉PS
Molecular Weight:749.536
Hs Code.:

Synonyms:(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

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Chemical Property of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

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Technology Process of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

There total 11 articles about (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404475-90-6
C₃₃H₃₈BrN₆O₉PS

: 1404473-96-6
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; for 10h;

Reference yield:

: 1156468-60-8
tert-butyl 4-{2-[6-amino-8-(1,3-benzodioxol-5-ylthio)-9H-purin-9-yl]ethyl}piperidine-1-carboxylate

: 1404473-96-6
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / acetic acid / 1 h / 20 °C

1.2: 1 h

2.1: triethylamine / dichloromethane; tetrahydrofuran / 20 °C

2.2: 6 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / N,N-dimethyl-formamide / 20 °C

4.1: trimethylsilyl bromide / dichloromethane / 10 h

With trimethylsilyl bromide; bromine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1404473-96-6
(2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-1-oxopropan-2-yl 3-(phosphonooxy)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: tetrahydrofuran; methanol / 20 °C / NaOAc-AcOH buffer

2.2: 2 h / 20 °C

3.1: silver carbonate / N,N-dimethyl-formamide / 100 °C

4.1: bromine / acetic acid / 1 h / 20 °C

4.2: 1 h

5.1: triethylamine / dichloromethane; tetrahydrofuran / 20 °C

5.2: 6 h

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / N,N-dimethyl-formamide / 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 10 h

With trimethylsilyl bromide; bromine; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; silver carbonate; dmap; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;