(R)-1-Boc-4-(aminocarboxymethyl)piperidine

Base Information

Chemical Name:(R)-1-Boc-4-(aminocarboxymethyl)piperidine
CAS No.:177702-21-5
Molecular Formula:C12H22 N2 O4
Molecular Weight:258.318
Hs Code.:2933399090
European Community (EC) Number:676-420-9
DSSTox Substance ID:DTXSID90477489
Nikkaji Number:J1.690.038I
Wikidata:Q76422690
Mol file:177702-21-5.mol

Synonyms:177702-21-5;(R)-1-Boc-4-(aminocarboxymethyl)piperidine;(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid;(2R)-2-amino-2-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]acetic acid;(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)aceticacid;(R)-4-(AMINO-CARBOXY-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(2r)-gly-4-pip(boc);SCHEMBL1770352;DTXSID90477489;CHA70221;MFCD08272929;AKOS015918672;AS-36954;CS-0171747;A848410;(R)-2-Amino-2-(1-BOC-piperidin-4-yl)acetic acid;4-Piperidineacetic acid, alpha-amino-1-[(1,1-dimethylethoxy)carbonyl]-, (alphaR)-

Suppliers and Price of (R)-1-Boc-4-(aminocarboxymethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 95%
1g
$ 1368.00

Matrix Scientific
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 95%
250mg
$ 480.00

Chemenu
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)aceticacid 97%
1g
$ 1136.00

American Custom Chemicals Corporation
(R)-4-(AMINO-CARBOXY-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
0.25G
$ 614.00

Alichem
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)aceticacid
250mg
$ 392.40

Alichem
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)aceticacid
5g
$ 4924.50

Alichem
(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)aceticacid
1g
$ 1708.50

AK Scientific
(R)-1-Boc-4-(aminocarboxymethyl)piperidine
1g
$ 1290.00

Total 15 raw suppliers

Chemical Property of (R)-1-Boc-4-(aminocarboxymethyl)piperidine

Chemical Property:

Vapor Pressure:1.92E-07mmHg at 25°C
Refractive Index:1.513
Boiling Point:397.9°C at 760 mmHg
PKA:2.30±0.10(Predicted)
Flash Point:194.5°C
PSA：92.86000
Density:1.181g/cm³
LogP:1.68360
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:258.15795719
Heavy Atom Count:18
Complexity:317

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Amino-2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)C(C(=O)O)N
Isomeric SMILES:CC(C)(C)OC(=O)N1CCC(CC1)[C@H](C(=O)O)N

Technology Process of (R)-1-Boc-4-(aminocarboxymethyl)piperidine

There total 5 articles about (R)-1-Boc-4-(aminocarboxymethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 161315-57-7
4-(R)-(azidocarboxymethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 177702-21-5
4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; under 2327.23 Torr; Autoclave;
DOI:10.1021/jm801394m

Reference yield: 82.0%

: 400888-22-4
4-((R)-benzyloxycarbonylamino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

: 177702-21-5
4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; at 20 ℃; for 16h; under 2585.74 Torr;
DOI:10.1016/S0957-4166(01)00425-6

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 177702-21-5
4-((R)-amino-carboxy-methyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / tetramethylguanidine / ethyl acetate / 42 h / 20 °C

2: H₂ / [(R,R)-Me-BPE-Rh-COD]OTf / methanol / 72 h / 20 °C / 4654.33 Torr

3: 98 percent / 1N LiOH / methanol / 20 h / 20 °C

4: 82 percent / H₂ / 5 percent Pd/C / ethanol; H₂O / 16 h / 20 °C / 2585.74 Torr

With lithium hydroxide; 1,1,3,3-tetramethylguanidine; hydrogen; palladium on activated charcoal; {(1,5-cyclooctadiene)Rh(1,2-bis((2R,5R)-2,5-dimethylphospholano)ethane)}triflate; In methanol; ethanol; water; ethyl acetate;
DOI:10.1016/S0957-4166(01)00425-6