1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine

Base Information

• Chemical Name: 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine
• CAS No.: 121353-95-5
• Molecular Formula: C₃₀H₂₉FN₂O₅
• Molecular Weight: 516.569
• Mol file: 121353-95-5.mol

Synonyms:1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine

Chemical Property of 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine

There total 4 articles about 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Thiocarbonic acid O-[(2R,3R,4S,5R)-4-fluoro-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester → 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine (121353-95-5)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 75 ℃; for 2h;

DOI:10.1021/jm00128a013

Reference yield:

Imidazole-1-carbothioic acid O-[(2R,3R,4S,5R)-4-fluoro-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester → 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine (121353-95-5)

Guidance literature:

With polymethylhydrosiloxane; 2,2'-azobis(isobutyronitrile); bis(tri-n-butyltin)oxide; In toluene; for 3.5h; Heating;

DOI:10.1021/jm00170a017

Reference yield:

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (69256-17-3,163252-36-6,2923-73-1) → 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-threo-pentofuranosyl>thymine (121353-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 6 h / 65 - 75 °C

2: dimethylformamide / 2.5 h / 80 °C

3: 2.7 g / azobisisobutyronitrile, bis(tributyltin) oxide, polymethylhydrosiloxane / toluene / 3.5 h / Heating

With pyridine; polymethylhydrosiloxane; 2,2'-azobis(isobutyronitrile); bis(tri-n-butyltin)oxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00170a017

upstream raw materials:

1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine

mono-4-methoxytrityl chloride

Downstream raw materials:

4-Amino-1-{(2R,3S,5S)-3-fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

1-(2,3-dideoxy-2-fluoro-threo-pentofuranosyl)thymine