sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

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Chemical Name:sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione
CAS No.:107325-11-1
Molecular Formula:C₂₂H₁₉N₂O₄S*Na
Molecular Weight:430.46
Hs Code.:

Synonyms:sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

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Chemical Property of sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

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Technology Process of sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

There total 8 articles about sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

: 107325-11-1
sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

Guidance literature:

Reference yield:

: 10572-16-4
3-(4-nitrophenoxy)propanoic acid

: 107325-11-1
sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) DMF, toluene, 90 deg C, 1 h, 2.) AcOEt, H₂O, RT

2: POCl₃ / toluene / 1 h / Heating

3: H₂ / 5 percent Pd/C / methanol / Ambient temperature

4: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

5: NaOAc / ethanol / 3 h / Heating

6: 2N aq. HCl, EtOH / 12 h / Heating

With copper(I) oxide; hydrogenchloride; thionyl chloride; ethanol; hydrogen bromide; hydrogen; sodium acetate; sodium carbonate; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00092a012

Reference yield:

: 3904-16-3
1-amino-1-phenyl-propan-2-on hydrochloride

: 107325-11-1
sodium salt of 5-{4-[2-(5-methyl-4-phenyl-2-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) SOCl₂, 2.) Na₂CO₃ / 1.) DMF, toluene, 90 deg C, 1 h, 2.) AcOEt, H₂O, RT

2: POCl₃ / toluene / 1 h / Heating

3: H₂ / 5 percent Pd/C / methanol / Ambient temperature

4: 1.) aq. NaNO₂, aq. HBr, 2.) Cu₂O / 1.) MeOH, acetone, 5 deg C, 30 min, 2.) MeOH, acetone, 38 deg C

5: NaOAc / ethanol / 3 h / Heating

6: 2N aq. HCl, EtOH / 12 h / Heating

With copper(I) oxide; hydrogenchloride; thionyl chloride; ethanol; hydrogen bromide; hydrogen; sodium acetate; sodium carbonate; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; toluene;
DOI:10.1021/jm00092a012