N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

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Chemical Name:N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide
CAS No.:349106-01-0
Molecular Formula:C₃₂H₃₉ClN₆O₆
Molecular Weight:639.151
Hs Code.:

N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

Synonyms:N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

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Chemical Property of N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

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Technology Process of N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

There total 10 articles about N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 349106-01-0
N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 47 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 11 h / Heating

2.1: 60 percent / aq. NaOH / H₂O / 1 h / 60 °C

3.1: 94.3 percent / DCC / tetrahydrofuran / 15 h / 20 °C

4.1: 64 percent / aq. KOH / H₂O / 3 h / 60 °C

5.1: CMC / tetrahydrofuran / 0.08 h / Heating

5.2: DMAP / tetrahydrofuran / Heating

6.1: sodium dithionate; K₂CO₃ / 1,1'-dioctadecyl-4,4'-bipyridinium dibromide / CH₂Cl₂; H₂O / 22 h / 35 °C

7.1: Et₃N / CH₂Cl₂

With sodium dithionate; potassium hydroxide; sodium hydroxide; potassium tert-butylate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; 1,1'-dioctadecyl-4,4'-bipyridinium dibromide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm060212s

Reference yield:

: 349110-82-3,147494-01-7
dimethyl 7-chloro-4-hydroxy-quinoline-2,3-dicarboxylate

: 349106-01-0
N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / aq. NaOH / H₂O / 1 h / 60 °C

2.1: 94.3 percent / DCC / tetrahydrofuran / 15 h / 20 °C

3.1: 64 percent / aq. KOH / H₂O / 3 h / 60 °C

4.1: CMC / tetrahydrofuran / 0.08 h / Heating

4.2: DMAP / tetrahydrofuran / Heating

5.1: sodium dithionate; K₂CO₃ / 1,1'-dioctadecyl-4,4'-bipyridinium dibromide / CH₂Cl₂; H₂O / 22 h / 35 °C

6.1: Et₃N / CH₂Cl₂

With sodium dithionate; potassium hydroxide; sodium hydroxide; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; 1,1'-dioctadecyl-4,4'-bipyridinium dibromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm060212s

Reference yield:

: 1027043-84-0
C₂₇H₂₈ClN₅O₇

: 349106-01-0
N-[(tert-butoxy)carbonylamino]-N-[(3-{[(tert-butyl)amino]carbonylamino}-phenyl)methyl][7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)(3-hydroxyquinolyl)]carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dithionate; K₂CO₃ / 1,1'-dioctadecyl-4,4'-bipyridinium dibromide / CH₂Cl₂; H₂O / 22 h / 35 °C

2: Et₃N / CH₂Cl₂

With sodium dithionate; potassium carbonate; triethylamine; 1,1'-dioctadecyl-4,4'-bipyridinium dibromide; In dichloromethane; water;
DOI:10.1021/jm060212s