1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

Base Information

Chemical Name:1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide
CAS No.:529505-89-3
Molecular Formula:C₂₃H₂₈N₄O₃S
Molecular Weight:440.566
Hs Code.:

Synonyms:1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

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Chemical Property of 1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

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Technology Process of 1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

There total 7 articles about 1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 529505-92-8
thiophene-2-carboxylic acid 3-{5-(cyclohexyl-methyl-carbamoyl)-2-[(thiophene-2-carbonyl)-amino]-benzoimidazol-1-yl}-propyl ester

: 529505-89-3
1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

Guidance literature:: With sodium hydroxide; In methanol; water;

Reference yield:

: 529505-85-9
N-cyclohexyl-4-fluoro-N-methyl-3-nitrobenzamide

: 529505-89-3
1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylsulfoxide / 90 °C

2: NH₄HCO₂ / Pd/C / ethanol

3: ethanol

4: pyridine

With pyridine; ammonium formate; triethylamine; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2007.04.045

Reference yield:

: 529505-90-6
N-cyclohexyl-4-(3-hydroxy-propylamino)-N-methyl-3-nitro-benzamide

: 529505-89-3
1-(3-hydroxy-propyl)-2-(thiophene-2-carbonyl)amino-1H-benzimidazole-5-carboxylic Acid cyclohexyl-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: NH₄HCO₂ / Pd/C / ethanol

2: ethanol

3: pyridine

With pyridine; ammonium formate; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.bmcl.2007.04.045