BENZYL TRANS-4-AMINOMETHYLCYCLOHEXYLCARBAMATE

Base Information

• Chemical Name: BENZYL TRANS-4-AMINOMETHYLCYCLOHEXYLCARBAMATE
• CAS No.: 177582-74-0
• Molecular Formula: C15H22 N2 O2
• Molecular Weight: 262.352
• Mol file: 177582-74-0.mol

Synonyms:Carbamicacid, [4-(aminomethyl)cyclohexyl]-, phenylmethyl ester, trans-; Carbamic acid,[trans-4-(aminomethyl)cyclohexyl]-, phenylmethyl ester (9CI);[trans-4-(Aminomethyl)cyclohexyl]carbamic acid benzyl ester

Chemical Property of BENZYL TRANS-4-AMINOMETHYLCYCLOHEXYLCARBAMATE

Chemical Property:

• Vapor Pressure: 1.77E-07mmHg at 25°C
• Refractive Index: 1.555
• Boiling Point: 426.5°C at 760 mmHg
• Flash Point: 211.7°C
• PSA: 64.35000
• Density: 1.11g/cm³
• LogP: 3.52150

Purity/Quality:

97% ^*data from raw suppliers

Benzyltrans-4-Aminomethylcyclohexylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-4-(Benzyloxycarbonylamino)cyclohexanemethylamine used as intermediate for chemical research.

Technology Process of BENZYL TRANS-4-AMINOMETHYLCYCLOHEXYLCARBAMATE

There total 1 articles about BENZYL TRANS-4-AMINOMETHYLCYCLOHEXYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(tert-butoxy)-N-({trans-4-[(phenylmethoxy)carbonylamino]cyclohexyl}methyl)carboxamide (192323-61-8) → benzyl ((1r,4r)-4-(aminomethyl)cyclohexyl)carbamate (177582-74-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 5h;

Reference yield: 97.0%

benzyl ((1r,4r)-4-(aminomethyl)cyclohexyl)carbamate (177582-74-0) + (S)-1-((S)-2-Benzyloxycarbonylamino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (177583-47-0) → [4-({[(S)-1-((S)-2-Benzyloxycarbonylamino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-cyclohexyl]-carbamic acid benzyl ester

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm970140s

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + benzyl ((1r,4r)-4-(aminomethyl)cyclohexyl)carbamate (177582-74-0) → benzyl 4-[(dimethylamino)methyl]cyclohexylcarbamate (1356953-43-9)

Guidance literature:

With formic acid; In water; for 2h; Reflux;

upstream raw materials:

(tert-butoxy)-N-({trans-4-[(phenylmethoxy)carbonylamino]cyclohexyl}methyl)carboxamide

Downstream raw materials:

N-[trans-4-({[(methylethyl)sulfonyl]amino}methyl)cyclohexyl](phenylmethoxy)carboxamide

benzyl 4-[(dimethylamino)methyl]cyclohexylcarbamate