4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

Base Information

Chemical Name:4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl
CAS No.:259143-05-0
Molecular Formula:C₂₈H₃₅FN₂O₂
Molecular Weight:450.597
Hs Code.:

Synonyms:4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

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Technology Process of 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

There total 9 articles about 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92-52-4,1594-86-1
biphenyl

: 259143-05-0
4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

Guidance literature:: Multi-step reaction with 5 steps

2: 25.4 percent / p-toluenesulfonic acid hydrate / toluene / 12 h / Heating

3: 80 percent / dioxane / 2 h / Heating

4: 44.2 percent / HCl / acetone / 12 h / 20 °C

5: 300 mg / potassium carbonate / dioxane / 70 °C

With hydrogenchloride; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; acetone; toluene; 1: Acylation / 2: Cyclization / 3: Substitution / 4: Hydrolysis / 5: Substitution;
DOI:10.1002/(SICI)1099-1344(19991230)42:13<1289::AID-JLCR287>3.0.CO;2-C

Reference yield:

: 259143-02-7
4-(α-bromoacetyl)-4'-[(4-methyl-1-piperidinyl)acetyl]biphenyl

: 259143-04-9
4-piperidinemethylfluoride

: 259143-05-0
4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

Guidance literature:: With potassium carbonate; In 1,4-dioxane; at 70 ℃;
DOI:10.1002/(SICI)1099-1344(19991230)42:13<1289::AID-JLCR287>3.0.CO;2-C

Reference yield:

: 6457-49-4
4-piperidinemethanol

: 259143-05-0
4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl

Guidance literature:: Multi-step reaction with 5 steps

2: 37.8 percent / triethylamine / CH₂Cl₂

3: 78 percent / tetraethylammonium fluoride dihydrate / acetonitrile / 6 h / 70 °C

4: trifluoroacetic acid / 0.17 h / 20 °C

5: 300 mg / potassium carbonate / dioxane / 70 °C

With tetraethylammonium fluoride; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile; 1: Acylation / 2: Tosylation / 3: Fluorination / 4: Hydrolysis / 5: Substitution;
DOI:10.1002/(SICI)1099-1344(19991230)42:13<1289::AID-JLCR287>3.0.CO;2-C