2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

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Chemical Name:2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid
CAS No.:1335214-99-7
Molecular Formula:C₄₁H₄₅N₃O₁₀
Molecular Weight:739.822
Hs Code.:

Synonyms:2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

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Chemical Property of 2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

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Technology Process of 2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

There total 4 articles about 2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1335214-82-8
methyl 2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoate

: 1335214-99-7
2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; for 5h; Reflux;
DOI:10.1016/j.ejmech.2011.06.025

Reference yield:

: 2150-46-1
Methyl 2,5-dihydroxybenzoate

: 1335214-99-7
2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / water; acetone / 5 h / Reflux

2: sodium azide / water; acetone / 6 h / Reflux

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 6 h / 20 °C

4: water; sodium hydroxide / tetrahydrofuran / 5 h / Reflux

With sodium azide; copper(ll) sulfate pentahydrate; water; potassium carbonate; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone; 3: Huisgen cycloaddition;
DOI:10.1016/j.ejmech.2011.06.025

Reference yield:

: 1309669-71-3
methyl 5-(3-azidopropoxy)-2-hydroxybenzoate

: 1335214-99-7
2-hydroxy-5-(3-(4-((((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methoxy)methyl)-1H-1,2,3-triazol-1-yl)propoxy)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water / 6 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 5 h / Reflux

With copper(ll) sulfate pentahydrate; water; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; 1: Huisgen cycloaddition;
DOI:10.1016/j.ejmech.2011.06.025