7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

Base Information

Chemical Name:7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline
CAS No.:1403491-64-4
Molecular Formula:C₂₉H₃₁N₅O₂
Molecular Weight:481.597
Hs Code.:

Synonyms:7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

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Chemical Property of 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

Chemical Property:

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Technology Process of 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

There total 12 articles about 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: 110-89-4
piperidine

: 1403491-35-9
2-chloro-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinoline

: 1403491-64-4
7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.5h;

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1403491-64-4
7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: Multi-step reaction with 10 steps

1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere

1.2: 4 h / 90 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h

3.1: 1 h / 130 °C

4.1: diphenylether / 0.33 h / Reflux

5.1: sodium hydroxide; water / ethanol; water / Reflux

5.2: 40 °C / pH 4

6.1: trichlorophosphate / 4 h / 20 °C / Heating

6.2: 0.5 h / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

8.1: potassium hydroxide / methanol / 0.33 h / Cooling with ice

8.2: 3 h

9.1: phosphorus pentachloride; trichlorophosphate / 5 h / 120 °C

10.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C

With phosphorus pentachloride; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;

Reference yield:

: 5399-03-1
2-iodo-1-methoxy-4-nitrobenzene

: 1403491-64-4
7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline

Guidance literature:: Multi-step reaction with 10 steps

1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere

1.2: 4 h / 90 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h

3.1: 1 h / 130 °C

4.1: diphenylether / 0.33 h / Reflux

5.1: sodium hydroxide; water / ethanol; water / Reflux

5.2: 40 °C / pH 4

6.1: trichlorophosphate / 4 h / 20 °C / Heating

6.2: 0.5 h / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

8.1: potassium hydroxide / methanol / 0.33 h / Cooling with ice

8.2: 3 h

9.1: phosphorus pentachloride; trichlorophosphate / 5 h / 120 °C

10.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C

With phosphorus pentachloride; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;