(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

Base Information

Chemical Name:(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine
CAS No.:137008-17-4
Molecular Formula:C₁₈H₂₃NO₂S
Molecular Weight:317.452
Hs Code.:

(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopent<f>indolizine

Synonyms:(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

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Technology Process of (5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

There total 4 articles about (5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 123642-83-1
(5aS,8aR,SS)-1H-9-<(4-methylphenyl)sulfinyl>-2,3,5,5a,6,7,8,8a-octahydro-5-oxocyclopentindolizine

: 137008-17-4
(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

Guidance literature:: With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; 1.) 25 deg C, 2 h, 2.) 50 deg C, 3 h;
DOI:10.1021/jo00025a011

Reference yield:

: 10267-94-4
ethyl cyclopent-1-enecarboxylate

: 137008-17-4
(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) a) -78 deg C, 15 min, b) 25 deg C, 2 h

2: 89 percent / NaCNBH₃, CF₃CO₂H, CH₃CO₂H / 1.) 25 deg C, 2 h, 2.) 50 deg C, 3 h

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; lithium diisopropyl amide;
DOI:10.1021/jo00025a011

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 137008-17-4
(5aS,8aR,9S,9aS,SR)-1H-decahydro-9-<(4-methylphenyl)sulfinyl>-5-oxocyclopentindolizine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ethylmagnesium bromide, diisopropylamine / 1.) THF, 0 deg C, 45 min, 2.) HMPA, 0 deg C, 30 min

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) a) -78 deg C, 15 min, b) 25 deg C, 2 h

3: 89 percent / NaCNBH₃, CF₃CO₂H, CH₃CO₂H / 1.) 25 deg C, 2 h, 2.) 50 deg C, 3 h

With ethylmagnesium bromide; sodium cyanoborohydride; acetic acid; diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide;
DOI:10.1021/jo00025a011