1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate
CAS No.:1093631-72-1
Molecular Formula:C₂₁H₂₁NO₅
Molecular Weight:367.401
Hs Code.:

Synonyms:1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

There total 5 articles about 1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1093631-71-0
1-(1,1-dimethylethyl) 2-methyl 6-{[(trifluoromethyl)sulfonyl]oxy}-1H-indole-1,2-dicarboxylate

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1093631-72-1
1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: With potassium phosphate; water; triphenylphosphine; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 0.5h;

Reference yield:

: 98081-83-5
methyl 6-methoxy-1H-indole-2-carboxylate

: 1093631-72-1
1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 18 h / 0 - 20 °C

1.3: pH 6

2.1: thionyl chloride / 1 h / Reflux

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: dmap / dichloromethane / 16 h / 20 °C

5.1: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 0.5 h / 100 °C

With dmap; potassium phosphate; thionyl chloride; water; boron tribromide; triethylamine; triphenylphosphine; palladium diacetate; In 1,4-dioxane; dichloromethane; 5.1: Suzuki Coupling;

Reference yield:

: 40047-23-2
6-hydroxy-1H-indole-2-carboxylic acid

: 1093631-72-1
1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: dmap / dichloromethane / 16 h / 20 °C

4: potassium phosphate; water; triphenylphosphine / palladium diacetate / 1,4-dioxane / 0.5 h / 100 °C

With dmap; potassium phosphate; thionyl chloride; water; triethylamine; triphenylphosphine; palladium diacetate; In 1,4-dioxane; dichloromethane; 4: Suzuki Coupling;