2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
• CAS No.: 134904-21-5
• Molecular Formula: C₁₆H₁₃ClN₂OS
• Molecular Weight: 316.811

Synonyms:2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property of 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property:

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Technology Process of 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

There total 7 articles about 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-Hydroxy-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (27285-14-9) → 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (134904-21-5)

Guidance literature:

With trichlorophosphate; phosphorus trichloride; at 110 - 120 ℃; for 18h;

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (134904-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene; toluene / 3 h / 120 °C

2: 10percent aq. KOH / 3 h / Heating

3: 47 percent / POCl₃, PCl₃ / 18 h / 110 - 120 °C

With potassium hydroxide; trichlorophosphate; phosphorus trichloride; In toluene; benzene;

Reference yield:

phenyl isocyanate (103-71-9) → 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (134904-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene; toluene / 3 h / 120 °C

2: 10percent aq. KOH / 3 h / Heating

3: 47 percent / POCl₃, PCl₃ / 18 h / 110 - 120 °C

With potassium hydroxide; trichlorophosphate; phosphorus trichloride; In toluene; benzene;

upstream raw materials:

2-Hydroxy-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

2-(3-phenyl-ureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

phenyl isocyanate

Downstream raw materials:

2-piperidyl-3-phenyl-4-oxo-3,4,5,6,7,8-hexahydrobenzothieno<2,3-d>pyrimidine

2-Morpholin-4-yl-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

2-(4-Methyl-piperazin-1-yl)-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

2-hydrazinyl-3-phenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

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