Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate

Base Information

• Chemical Name: Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate
• CAS No.: 174808-64-1
• Molecular Formula: C₂₄H₂₁NO₃
• Molecular Weight: 371.436
• Mol file: 174808-64-1.mol

Synonyms:Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate

Chemical Property of Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate

There total 3 articles about Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Ethyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate (174808-57-2,174808-62-9,174808-63-0) + benzyl alcohol (100-51-6,185532-71-2) → Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate (174808-64-1)

Guidance literature:

With sodium;

DOI:10.1039/c39940000653

Reference yield:

2-methoxy-1-naphthaldehyde (5392-12-1) → Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate (174808-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / KOAc, MeNH₂*HCl, HC(OMe)3 / 7 h / Heating

2: 83 percent / DBU / tetrahydrofuran / 120 h / 20 °C

3: 89 percent / Na / 4 h / 105 °C

With methylamine hydrochloride; potassium acetate; sodium; 1,8-diazabicyclo[5.4.0]undec-7-ene; trimethyl orthoformate; In tetrahydrofuran;

DOI:10.1039/p19960000183

Reference yield:

2-Methoxy-1-(2-nitroprop-1-enyl)naphthalene (102248-84-0) → Benzyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate (174808-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / DBU / tetrahydrofuran / 120 h / 20 °C

2: 89 percent / Na / 4 h / 105 °C

With sodium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1039/p19960000183

upstream raw materials:

Ethyl (+/-)-3-(2'-methoxy-1'-naphthyl)-4-methylpyrrole-2-carboxylate

benzyl alcohol

2-methoxy-1-naphthaldehyde

2-Methoxy-1-(2-nitroprop-1-enyl)naphthalene