Carbamic acid, [2-(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1S-

Base Information

Chemical Name:Carbamic acid, [2-(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1S-
CAS No.:177472-48-9
Molecular Formula:C₉H₁₇NO₃
Molecular Weight:187.239
Hs Code.:
Mol file:177472-48-9.mol

Synonyms:(1'R,2'S)-<2-(tert-butoxycarbonylamino)-cyclopropyl>-methanol;(1'R,2'S)-[2-(tert-butoxycarbonylamino)-cyclopropyl]-methanol;((1S,2R)-2-Hydroxymethyl-cyclopropyl)-carbamic acid tert-butyl ester;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [2-(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1S-

Chemical Property:

PSA：58.56000
LogP:1.28280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1S-

There total 4 articles about Carbamic acid, [2-(hydroxymethyl)cyclopropyl]-, 1,1-dimethylethyl ester, (1S- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: methyl (1R,2S)-2-(tert-butoxycarbonylamino)-1-cyclopropane carboxylate

: 177472-48-9,177472-60-5
(+)-(1S,2R)-cis-<2-(tert.-butoxycarbonylamino)-cyclopropyl>-methanol

Guidance literature:: With diisobutylaluminium hydride; at -78 ℃; for 3h;
DOI:10.1016/S0040-4020(01)89583-1

Reference yield:

: 177472-60-5
(+/-)-(1RS,2RS)-cis-<2-(tert.-butoxycarboamino)-cyclopropyl>-methanol

: 177472-48-9,177472-60-5
(+)-(1S,2R)-cis-<2-(tert.-butoxycarbonylamino)-cyclopropyl>-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / 4 h / 25 °C

2: 0.5 N NaOH / H₂O / lipase P

With pyridine; sodium hydroxide; In water;
DOI:10.1016/0040-4020(96)00272-4

Reference yield:

: cis-methyl-2-<(tert-butoxycarbonyl)amino>-1-cyclopropane-carboxylate

: 177472-48-9,177472-60-5
(+)-(1S,2R)-cis-<2-(tert.-butoxycarbonylamino)-cyclopropyl>-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / DIBAH / toluene / 3 h / -78 °C

2: 94 percent / pyridine / 4 h / 25 °C

3: 0.5 N NaOH / H₂O / lipase P

With pyridine; sodium hydroxide; diisobutylaluminium hydride; In water; toluene;
DOI:10.1016/0040-4020(96)00272-4