6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine

Base Information

• Chemical Name: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine
• CAS No.: 179928-10-0
• Molecular Formula: C₁₄H₁₁BrN₂O₂S
• Molecular Weight: 351.224
• Mol file: 179928-10-0.mol

Synonyms:6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine

Chemical Property of 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine

There total 3 articles about 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-bromopyrrole-2-carboxaldehyde (931-33-9) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine (179928-10-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/0040-4039(96)00812-X

Reference yield: 79.0%

4-bromopyrrole-2-carboxaldehyde (931-33-9) + p-tolylsulfonylmethyl isocyanide (5697-44-9) → 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine (179928-10-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jo9907080

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) → 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine (179928-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrahydrofuran / -78 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 20 °C

With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2016.02.023

upstream raw materials:

4-bromopyrrole-2-carboxaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile

p-tolylsulfonylmethyl isocyanide

2-pyrrole aldehyde

Downstream raw materials:

6-methyl-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine

6-methylpyrrolo[1,2-c]pyrimidine

methyl 2-formyl-4-pyrrolcarboxylate