11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

Base Information

Chemical Name:11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol
CAS No.:133034-63-6
Molecular Formula:C₂₈H₃₉NOS₂
Molecular Weight:469.756
Hs Code.:

Synonyms:11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

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Chemical Property of 11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

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Technology Process of 11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

There total 6 articles about 11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133034-62-5
11β-[4-(N,N-dimethylamino)phenyl]-17β-hydroxy-5α-estran-4-en-3-one

: 540-63-6
ethane-1,2-dithiol

: 133034-63-6
11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

Guidance literature:: With sodium hydroxide; toluene-4-sulfonic acid; In acetic acid;

Reference yield:

: 89328-06-3
11β-(4-dimethylaminophenyl)-17β-hydroxy-4,9-estradien-3-one

: 133034-63-6
11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium; ammonia / tetrahydrofuran / 0.33 h / -78 - -60 °C / Inert atmosphere

2: toluene-4-sulfonic acid / benzene / Inert atmosphere; Reflux

3: toluene-4-sulfonic acid; acetic acid / 2 h / 20 °C / Inert atmosphere

With ammonia; lithium; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; benzene; 1: |Birch Reduction;
DOI:10.1021/acs.jmedchem.8b00743

Reference yield:

: C₂₀H₂₈O₄

: 133034-63-6
11β-[4-(Dimethylamino)phenyl]-3,3-[1,2-ethanediylbis(thio)]-4-estren-17β-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; iodine / tetrahydrofuran; toluene / 2.33 h / 60 °C / Inert atmosphere

1.2: 1 h / 0 - 25 °C / Inert atmosphere

2.1: water; acetic acid / 1 h / 55 °C / Inert atmosphere

3.1: lithium; ammonia / tetrahydrofuran / 0.33 h / -78 - -60 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / benzene / Inert atmosphere; Reflux

5.1: toluene-4-sulfonic acid; acetic acid / 2 h / 20 °C / Inert atmosphere

With ammonia; water; iodine; lithium; toluene-4-sulfonic acid; magnesium; acetic acid; In tetrahydrofuran; toluene; benzene; 3.1: |Birch Reduction;
DOI:10.1021/acs.jmedchem.8b00743