4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole

Base Information

• Chemical Name: 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole
• CAS No.: 211256-72-3
• Molecular Formula: C₁₂H₆BrCl₂F₃N₂O₂
• Molecular Weight: 417.997

Synonyms:4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole

Chemical Property of 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole

Chemical Property:

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Technology Process of 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole

There total 2 articles about 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4-dichlorobenzoyl chloride (89-75-8) + 4-bromo-1-methyl-5-hydroxypyrazole (122431-43-0) → 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole (211256-72-3)

Guidance literature:

With triethylamine; In chloroform; at 0 - 20 ℃; for 1h;

DOI:10.1080/00397919808007030

Reference yield:

2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol (122431-37-2) → 4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole (211256-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NBS / CHCl₃ / 1 h / -5 °C

2: 88 percent / Et₃N / CHCl₃ / 1 h / 0 - 20 °C

With N-Bromosuccinimide; triethylamine; In chloroform; 1: Bromination / 2: Esterification;

DOI:10.1080/00397919808007030

Reference yield: 64.0%

4-bromo-5-(2,4-dichlorobenzoyl)oxy-1-methyl-3-trifluoromethylpyrazole (211256-72-3) → 4-(2,4-dichlorobenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole (211256-75-6)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; for 3h; Heating;

DOI:10.1080/00397919808007030

upstream raw materials:

2,4-dichlorobenzoyl chloride

4-bromo-1-methyl-5-hydroxypyrazole

2-methyl-5-trifluoromethyl-2H-pyrazol-3-ol

Downstream raw materials:

4-(2,4-dichlorobenzoyl)-1-methyl-5-hydroxy-3-trifluoromethylpyrazole

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