benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

Base Information

Chemical Name:benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate
CAS No.:737777-32-1
Molecular Formula:C₂₅H₂₇NO₃S
Molecular Weight:421.56
Hs Code.:

benzyl N-[(1S,2S,R<sub>s</sub>)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

Synonyms:benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

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Technology Process of benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

There total 4 articles about benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 737777-24-1
(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propylamine

: 737777-32-1
benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/jo049666s

Reference yield:

: 1519-40-0
(+)-(R)-ethyl p-tolyl sulfoxide

: 737777-32-1
benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iPr₂NLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 50 percent / tetrahydrofuran; hexane / 24 h / 0 °C

2.1: 90 percent / trifluoroacetic acid / methanol / 3 h / 0 °C

3.1: 86 percent / NaH / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo049666s

Reference yield:

: (S)-N-[(E)-1-phenylethylidene]-2-methoxy-1-naphthalenesulfinamide

: 737777-32-1
benzyl N-[(1S,2S,R_s)-1-methyl-1-phenyl-2-(p-tolylsulfinyl)propyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iPr₂NLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 50 percent / tetrahydrofuran; hexane / 24 h / 0 °C

2.1: 90 percent / trifluoroacetic acid / methanol / 3 h / 0 °C

3.1: 86 percent / NaH / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo049666s