4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

Base Information

Chemical Name:4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine
CAS No.:1309774-99-9
Molecular Formula:C₂₂H₁₇N₅S
Molecular Weight:383.476
Hs Code.:

Synonyms:4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

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Chemical Property of 4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

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Technology Process of 4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

There total 5 articles about 4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1309774-78-4
4-chloro-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

: 5122-94-1
4-biphenylboronic acid

: 1309774-99-9
4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1055/s-0030-1258432

Reference yield:

: 74002-70-3
3-thioxo-3,4-dihydro-pyrazine-2-carbonitrile

: 1309774-99-9
4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 1 h / 20 °C

1.2: 5 h / Reflux

2.1: 1,2-dichloro-ethane / 6 h / Reflux

3.1: hydrogenchloride / 1,2-dichloro-ethane / 24 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 24 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium iodide; In 1,2-dichloro-ethane; acetone; toluene; 4.1: Suzuki-Miyaura coupling;
DOI:10.1055/s-0030-1258432

Reference yield:

: 56881-34-6
7-aminothieno[2,3-b]pyrazine-6-carbonitrile

: 1309774-99-9
4-(biphenyl-4-yl)-2-(dimethylamino)pyrazino[2',3':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / 6 h / Reflux

2: hydrogenchloride / 1,2-dichloro-ethane / 24 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 24 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dichloro-ethane; toluene; 3: Suzuki-Miyaura coupling;
DOI:10.1055/s-0030-1258432