N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Base Information

Chemical Name:N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide
CAS No.:1361413-38-8
Molecular Formula:C₂₇H₁₇ClF₃N₃O₄S₂
Molecular Weight:604.03
Hs Code.:

Synonyms:N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

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Chemical Property of N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

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Technology Process of N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

There total 9 articles about N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5000-66-8
2-chlorophenacyl bromide

: 1361413-38-8
N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C

2.2: 48 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 1153070-21-3
2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid

: 1361413-97-9
3-{2-amino-5-[(2-chlorophenyl)carbonyl]-1,3-thiazol-4-yl}benzonitrile

: 1361413-38-8
N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: 2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid; 3-{2-amino-5-[(2-chlorophenyl)carbonyl]-1,3-thiazol-4-yl}benzonitrile; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃;

2-(4-((2,2,2-trifluoroethyl)sulfonyl)phenyl)acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; for 48h;

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1361413-38-8
N-[5-[(2-chlorophenyl)carbonyl]-4-(3-cyanophenyl)-1,3-thiazol-2-yl]-2-{4-[(2,2,2-trifluoroethyl)sulfonyl]phenyl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C

1.2: 20 - 45 °C

2.1: potassium hydroxide / ethanol; water / 20 h / Reflux

2.2: Cooling with ice

3.1: sulfuric acid / 0.75 h / 70 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6.1: hydrogenchloride / acetic acid / 1.5 h / 105 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C

7.2: 48 h

With hydrogenchloride; sulfuric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium nitrite; In ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;