1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine

Base Information

• Chemical Name: 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine
• CAS No.: 1358694-04-8
• Molecular Formula: C₂₅H₂₃F₂N₃O₂
• Molecular Weight: 435.473
• Mol file: 1358694-04-8.mol

Synonyms:1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine

Chemical Property of 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine

There total 7 articles about 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

N-(3,5-difluorobenzyl)pyrimidin-2-amine (1358694-18-4) + 2-bromo-3-(3',5'-dimethoxybiphenyl-3-yl)propanal (1358694-19-5) → 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine (1358694-04-8)

Guidance literature:

N-(3,5-difluorobenzyl)pyrimidin-2-amine; 2-bromo-3-(3',5'-dimethoxybiphenyl-3-yl)propanal; In acetonitrile; at 150 ℃; for 1.25h; Microwave irradiation;

With hydrazine hydrate; In acetonitrile; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.ejmech.2011.12.016

Reference yield:

methyl 3-(3'-bromophenyl)-propionate (151583-29-8) → 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine (1358694-04-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 5 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: pyridinium chlorochromate / dichloromethane / 0 °C

4.1: hydrogenchloride; 5,5-dibromobarbituric acid / 1,4-dioxane; diethyl ether / 20 h / 20 °C

5.1: acetonitrile / 1.25 h / 150 °C / Microwave irradiation

5.2: 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5,5-dibromobarbituric acid; sodium carbonate; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; toluene; acetonitrile; 1.1: Suzuki coupling;

DOI:10.1016/j.ejmech.2011.12.016

Reference yield:

3-(3',5'-dimethoxybiphenyl-3-yl)propan-1-ol (1358694-45-7) → 1-(3,5-difluorobenzyl)-4-((3',5'-dimethoxybiphenyl-3-yl)methyl)-1H-imidazol-2-amine (1358694-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 0 °C

2.1: hydrogenchloride; 5,5-dibromobarbituric acid / 1,4-dioxane; diethyl ether / 20 h / 20 °C

3.1: acetonitrile / 1.25 h / 150 °C / Microwave irradiation

3.2: 0.25 h / 100 °C / Microwave irradiation

With hydrogenchloride; 5,5-dibromobarbituric acid; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2011.12.016

upstream raw materials:

methyl 3-(3'-bromophenyl)-propionate

N-(3,5-difluorobenzyl)pyrimidin-2-amine

2-bromo-3-(3',5'-dimethoxybiphenyl-3-yl)propanal

methyl 3-(3',5'-dimethoxybiphenyl-3-yl)propanoate