(1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid

Base Information

• Chemical Name: (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid
• CAS No.: 112455-93-3
• Molecular Formula: C₂₀H₁₈O₃
• Molecular Weight: 306.361
• Mol file: 112455-93-3.mol

Synonyms:(1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid

Chemical Property of (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid

There total 2 articles about (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<(trimethylsilyl)methyl>-3-(trimethylsilyl)prop-2-en-1-yl methyl carbonate (112373-93-0) + 1,3-diphenyl-propen-3-one (614-47-1) → (1R,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid (112455-92-2) + (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid (112455-93-3)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 80 ℃; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00213a038

Reference yield:

methyl 1-(trimethylsilyl)-2-<(trimethylsilyl)methyl>prop-1-en-3-yl carbonate (103693-94-3,112373-93-0) + 1,3-diphenyl-propen-3-one (614-47-1) → (1R,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid (112455-92-2) + (1S,2S,3R)-3-Benzoyl-5-methylene-2-phenyl-cyclopentanecarboxylic acid (112455-93-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 80 ℃; Yield given;

DOI:10.1021/ja00279a070

upstream raw materials:

methyl 1-(trimethylsilyl)-2-<(trimethylsilyl)methyl>prop-1-en-3-yl carbonate

1,3-diphenyl-propen-3-one

2-<(trimethylsilyl)methyl>-3-(trimethylsilyl)prop-2-en-1-yl methyl carbonate