ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Base Information

Chemical Name:ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate
CAS No.:1040543-17-6
Molecular Formula:C₁₃H₁₁FN₂O₄
Molecular Weight:278.24
Hs Code.:

Synonyms:ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

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Chemical Property of ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

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Technology Process of ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

There total 1 articles about ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1040543-11-0
ethyl 3-{(2Z)-2-[2-(ethyloxy)-1-(4-fluorophenyl)-2-oxoethylidene]hydrazino}-3-oxopropanoate

: 1040543-17-6
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Guidance literature:: ethyl 3-{(2Z)-2-[2-(ethyloxy)-1-(4-fluorophenyl)-2-oxoethylidene]hydrazino}-3-oxopropanoate; With potassium hexamethylsilazane; In 1,4-dioxane; at 20 ℃; for 2.5h; Heating / reflux;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield: 97.0%

: 1040543-17-6
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

: 395-44-8
o-trifluoromethylbenzyl bromide

: 1040544-19-1
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-4-pyridazinecarboxylate

Guidance literature:: ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.75h;

o-trifluoromethylbenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 31.0%

: 1040543-17-6
ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

: 2567-29-5
p-phenylbenzyl bromide

: ethyl 2-(4-biphenylmethyl)-6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Guidance literature:: ethyl 6-(4-fluorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-4-pyridazinecarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.75h;

p-phenylbenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 20 ℃;