1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Base Information

Chemical Name:1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine
CAS No.:1361189-50-5
Molecular Formula:C₁₇H₂₁N₅O
Molecular Weight:311.387
Hs Code.:

Synonyms:1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Suppliers and Price of 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

There total 4 articles about 1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1361189-41-4
1-[4-(2-aminopyrimidin-5-yl)phenyl]-3,3-dimethylcyclobutanecarbonitrile

: 1361189-50-5
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Guidance literature:: With hydroxylamine; In ethanol; water; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm501185j

Reference yield:

: 5434-27-5
1,3-dibromo-2,2-dimethyl-propane

: 1361189-50-5
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere; Heating

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / 90 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; sodium hydride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm501185j

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1361189-50-5
1-[4-(2-aminopyrimidin-5-yl)phenyl]-N-hydroxy-3,3-dimethylcyclobutanecarboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: 16 h / Inert atmosphere; Heating

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / 90 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: hydroxylamine / ethanol; water / 16 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; sodium hydride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm501185j