5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile

Base Information

• Chemical Name: 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile
• CAS No.: 93683-90-0
• Molecular Formula: C₁₈H₂₀N₄
• Molecular Weight: 292.384

Synonyms:5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile

Chemical Property of 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile

There total 3 articles about 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-Benzyl-5'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile (93683-77-3) → 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile (93683-90-0)

Guidance literature:

With hydrogenchloride; iron; for 1h; Heating;

DOI:10.1021/jm00380a018

Reference yield:

2-benzylpiperidine (32838-55-4) → 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile (93683-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 72 percent / Fe, conc. aq. HCl / 1 h / Heating

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol;

DOI:10.1021/jm00380a018

Reference yield:

6-chloro-3-nitropicolinonitrile (93683-65-9) → 5'-Amino-2-benzyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile (93683-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 72 percent / Fe, conc. aq. HCl / 1 h / Heating

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol;

DOI:10.1021/jm00380a018

upstream raw materials:

2-Benzyl-5'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-carbonitrile

2-benzylpiperidine

6-chloro-3-nitropicolinonitrile

Downstream raw materials:

6-(2-Benzyl-piperidin-1-yl)-pyrido[3,2-d]pyrimidine-2,4-diamine

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