(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester
CAS No.:147593-04-2
Molecular Formula:C₁₃H₂₀O₄
Molecular Weight:240.299
Hs Code.:

Synonyms:(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

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Chemical Property of (1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

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Technology Process of (1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

There total 9 articles about (1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 147593-03-1
(7R,8S)-6,6,8-Trimethyl-7-(2-oxo-ethyl)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid methyl ester

: 147593-04-2
(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/0040-4020(96)00735-1

Reference yield:

: 147592-98-1
(1S,7aS)-1-tert-Butoxy-4,4,7a-trimethyl-1,2,4,6,7,7a-hexahydro-inden-5-one

: 147593-04-2
(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 83.4 percent / H₂ / 10percent Pd/C / benzene; heptane / 30 h / 2585.7 Torr / Ambient temperature

2: 100 percent / BF₃*Et₂O / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 96 percent / TsOH / benzene / 0.58 h / Heating

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, from -60 deg C to 0 deg C

5: 93 percent / collidine / CH₂Cl₂ / 0.17 h

6: 1.) O₃, Py, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, from -78 deg C to RT

7: aq. NaIO₄ / tetrahydrofuran / 0.17 h / Ambient temperature

8: diethyl ether / 0.08 h / 0 °C

9: 97 percent / aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; 2,3,5-trimethyl-pyridine; hydrogenchloride; sodium periodate; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; ozone; dimethyl sulfoxide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; n-heptane; dichloromethane; benzene;
DOI:10.1016/0040-4020(96)00735-1

Reference yield:

: 147593-02-0
C₁₄H₂₂O₄

: 147593-04-2
(1S,2R)-1,3,3-Trimethyl-4-oxo-2-(2-oxo-ethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaIO₄ / tetrahydrofuran / 0.17 h / Ambient temperature

2: diethyl ether / 0.08 h / 0 °C

3: 97 percent / aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

With hydrogenchloride; sodium periodate; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4020(96)00735-1