tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

Base Information

Chemical Name:tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate
CAS No.:1334180-63-0
Molecular Formula:C₂₀H₂₆N₂O₅
Molecular Weight:374.437
Hs Code.:

Synonyms:tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

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Chemical Property of tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

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Technology Process of tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

There total 6 articles about tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1334180-61-8
tert-butyl 2-diazo-5-[(2E)-3-methyl-4-oxobut-2-enyloxy]-3-oxo-5-phenylpentanoate

: 1334180-63-0
tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In ethyl acetate; at 50 ℃; for 5.5h; Inert atmosphere;
DOI:10.1002/chem.201101082

Reference yield:

: C₁₈H₂₂N₂O₇

: 1334180-63-0
tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / dichloromethane / 20 h / -78 - 20 °C / Inert atmosphere

2: dichloromethane / 50 h / 20 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride; acetic acid / ethyl acetate / 5.5 h / 50 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; In dichloromethane; ethyl acetate; 2: Wittig reaction;
DOI:10.1002/chem.201101082

Reference yield:

: 1334180-59-4
tert-butyl 2-diazo-3-oxo-5-(2-oxoethoxy)-5-phenylpentanoate

: 1334180-63-0
tert-butyl 2-diazo-5-[(2E)-3-methyl-4-hydroxybut-2-enyloxy]-3-oxo-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 50 h / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride; acetic acid / ethyl acetate / 5.5 h / 50 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; ethyl acetate; 1: Wittig reaction;
DOI:10.1002/chem.201101082