4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide

Base Information

• Chemical Name: 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide
• CAS No.: 439118-23-7
• Molecular Formula: C₃₁H₃₃ClN₄O₆
• Molecular Weight: 593.079
• Mol file: 439118-23-7.mol

Synonyms:4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide

Chemical Property of 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide

There total 13 articles about 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide (439118-21-5) → 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide (439118-23-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1021/jm049423s

Reference yield:

5-hydroxy-5H-indeno[1,2-b]pyridine-5-carboxylic acid hydrazide (439118-20-4) → 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide (439118-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C / pH 1 - 2

1.2: 85 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C

2.1: meta-chloroperoxybenzoic acid / CH₂Cl₂ / 16 h / 0 - 20 °C

With hydrogenchloride; n-Amyl nitrite; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm049423s

Reference yield:

4-aza-9-trimethylsiloxy-9-cyanofluorene (439118-19-1) → 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide (439118-23-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 4.4 g / HCl(gas) / 4 h / 0 - 20 °C

2.1: 85 percent / hydrazine / 0.5 h / 50 °C

3.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C / pH 1 - 2

3.2: 85 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C

4.1: meta-chloroperoxybenzoic acid / CH₂Cl₂ / 16 h / 0 - 20 °C

With hydrogenchloride; n-Amyl nitrite; 3-chloro-benzenecarboperoxoic acid; hydrazine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm049423s

upstream raw materials:

4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

5-hydroxy-5H-indeno[1,2-b]pyridine-5-carboxylic acid hydrazide

4-aza-9-trimethylsiloxy-9-cyanofluorene

2-chloro-3-pyridinecarbonitrile