(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

Base Information

Chemical Name:(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol
CAS No.:263340-61-0
Molecular Formula:C₂₅H₄₀O₂
Molecular Weight:372.591
Hs Code.:

Synonyms:(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

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Chemical Property of (1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

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Technology Process of (1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

There total 6 articles about (1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 263340-59-6
(1R,4R,7aR)-4-Benzyloxy-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-2,4,5,6,7,7a-hexahydro-1H-indene

: (1R,3R,3aR,7R,7aR)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

: 263340-61-0
(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

Guidance literature:: (1R,4R,7aR)-4-Benzyloxy-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-2,4,5,6,7,7a-hexahydro-1H-indene; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium hydroxide; dihydrogen peroxide; In ethanol; water; for 1h; Heating;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F

Reference yield:

: 66251-18-1
Grundmann's ketone

: 263340-61-0
(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiI; HN(TMS)2 / CH₂Cl₂ / 3 h

2.1: 84 percent / tetrahydrofuran; pyridine / 0.5 h / -78 °C

3.1: 83 percent / MCPBA / CH₂Cl₂ / 0.5 h

4.1: 80 percent / NaBH₄; CeCl₃*7H₂O / methanol / 1 h

5.1: 90 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 3 h / Heating

6.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

6.2: 62 percent / H₂O₂; NaOH / ethanol; H₂O / 1 h / Heating

With sodium tetrahydroborate; cerium(III) chloride; dimethylsulfide borane complex; tetra-(n-butyl)ammonium iodide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium iodide; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1.1: Silylation / 2.1: Selenenylation / 3.1: Elimination / 4.1: Reduction / 5.1: Etherification / 6.1: Hydroboration / 6.2: Oxidation;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F

Reference yield:

: 93922-90-8
De-A,B-cholest-14-en-8-one

: 263340-61-0
(1S,3R,3aR,7R,7aS)-7-Benzyloxy-3-((R)-1,5-dimethyl-hexyl)-3a-methyl-octahydro-inden-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / NaBH₄; CeCl₃*7H₂O / methanol / 1 h

2.1: 90 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 3 h / Heating

3.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

3.2: 62 percent / H₂O₂; NaOH / ethanol; H₂O / 1 h / Heating

With sodium tetrahydroborate; cerium(III) chloride; dimethylsulfide borane complex; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; methanol; 1.1: Reduction / 2.1: Etherification / 3.1: Hydroboration / 3.2: Oxidation;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F