2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE

Base Information

• Chemical Name: 2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE
• CAS No.: 176860-57-4
• Molecular Formula: C₈H₈Cl₂N₂O
• Molecular Weight: 219.07
• Hs Code.: 2925290090
• Mol file: 176860-57-4.mol

Synonyms:2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE

Chemical Property of 2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE

Chemical Property:

• Vapor Pressure: 5.01E-07mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 397.3°Cat760mmHg
• Flash Point: 194.1°C
• PSA: 56.11000
• Density: 1.45g/cm³
• LogP: 2.98260

Purity/Quality:

99% ^*data from raw suppliers

2-(3,4-dichlorophenyl)-N''-hydroxyethanimidamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE

There total 3 articles about 2-(3,4-DICHLORO-PHENYL)-N-HYDROXY-ACETAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 3,4-Dichlorophenyl-acetamidoxime hydrochloride (176860-57-4,925252-75-1)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In methanol; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.05.061

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → 2-(3,4-dichlorophenyl)-N-hydroxyethanimidamide (925252-75-1,176860-57-4)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; for 48h; Heating;

DOI:10.1021/jm990229t

Reference yield:

→ 3,4-Dichlorophenyl-acetamidoxime hydrochloride (176860-57-4,925252-75-1)

Guidance literature:

upstream raw materials:

3,4-dichloro-benzeneacetonitrile

Refernces

• 1、 Wang, Yujie,Rong, Jie,Zhang, Bin,Hu, Liming,Wang, Xiaoli,Zeng, Chengchu. "Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors". . p. 735 - 741. Retrieved 2015/02/19.
• 2、 Vu, Chi B.,Corpuz, Evelyn G.,Merry, Taylor J.,Pradeepan, Selvaluxmi G.,Bartlett, Catherine,Bohacek, Regine S.,Botfield, Martyn C.,Eyermann, Charles J.,Lynch, Berkley A.,MacNeil, Ian A.,Ram, Mary K.,Van Schravendijk, Marie Rose,Violette, Shelia,Sawyer, Tomi K.. "Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70". . p. 4088 - 4098. Retrieved 2007/10/03.