N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

Base Information

Chemical Name:N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide
CAS No.:1370714-06-9
Molecular Formula:C₂₃H₂₀N₄O₄S₂
Molecular Weight:480.568
Hs Code.:

Synonyms:N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

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Chemical Property of N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

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Technology Process of N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

There total 7 articles about N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 691361-76-9
2-amino-5-(methanesulfonylamino)benzenesulfonamide

: 10511-51-0
1-Benzylindole-3-carboxaldehyde

: 1370714-06-9
N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

Guidance literature:: With sodium hydrogensulfite; In N,N-dimethyl acetamide; at 150 ℃; for 2h;
DOI:10.1016/j.bmc.2012.01.031

Reference yield:

: 120-72-9
indole

: 1370714-06-9
N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / Cooling with ice

1.2: 2 h / 10 - 35 °C

1.3: Cooling with ice; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 2 h

3.1: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C

With sodium hydride; sodium hydrogensulfite; trichlorophosphate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil; 1.1: Vilsmeier-Haack reaction / 1.2: Vilsmeier-Haack reaction;
DOI:10.1016/j.bmc.2012.01.031

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1370714-06-9
N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 2 h

2.1: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C

With sodium hydride; sodium hydrogensulfite; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.031