N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

Base Information

Chemical Name:N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride
CAS No.:1263131-95-8
Molecular Formula:C₂₅H₂₆N₄O₅
Molecular Weight:462.505
Hs Code.:

Synonyms:N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

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Chemical Property of N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

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Technology Process of N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

There total 6 articles about N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1192928-01-0
N-3-(benzoylamino-4-methylphenylaminocarbonothioyl)-3,4,5-trimethoxybenzamide

: 1263131-95-8
N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

Guidance literature:: N-3-(benzoylamino-4-methylphenylaminocarbonothioyl)-3,4,5-trimethoxybenzamide; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere; Cooling with ice;

With hydrogenchloride; In diethyl ether; ethyl acetate; Inert atmosphere;
DOI:10.1021/jm2013369

Reference yield:

: 4771-07-7
N-(2-methyl-5-nitrophenyl)benzamide

: 1263131-95-8
N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; ammonium formate / isopropyl alcohol / Inert atmosphere; Microwave irradiation

2.1: acetone / 1 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere

With palladium 10% on activated carbon; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In isopropyl alcohol; acetone; acetonitrile;
DOI:10.1021/jm2013369

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 1263131-95-8
N-(N-(3-Bbenzamido-4-methylphenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / 0.33 h / Inert atmosphere; Reflux

2.1: acetone / 1 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 5 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetone; acetonitrile;
DOI:10.1021/jm2013369