ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

Base Information

Chemical Name:ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate
CAS No.:1415034-35-3
Molecular Formula:C₁₈H₁₅Cl₂N₃O₂
Molecular Weight:376.242
Hs Code.:

Synonyms:ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

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Chemical Property of ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

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Technology Process of ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

There total 6 articles about ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1415034-32-0
ethyl 2-hydroxy-2-[5-methyl-1-oxo-1H-pyrrolizin-2(3H)-ylidene]acetate

: 5446-18-4
2,4-dichlorophenyl hydrazine hydrochloride

: 1415034-35-3
ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

Guidance literature:: In ethanol; at 80 ℃; for 48h;
DOI:10.1055/s-0032-1316703

Reference yield:

: 17266-64-7
1,2-dihydro-1-pyrrolizinone

: 1415034-35-3
ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / tetrahydrofuran / -50 - -10 °C

2: palladium diacetate; ruphos; caesium carbonate / water; toluene / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

3: sodium; ethanol / 1 h / 20 °C

4: ethanol / 48 h / 80 °C

With N-Bromosuccinimide; ethanol; palladium diacetate; sodium; caesium carbonate; ruphos; In tetrahydrofuran; ethanol; water; toluene; 2: |Suzuki Coupling / 3: |Claisen Condensation;
DOI:10.1055/s-0032-1316703

Reference yield:

: 1415034-30-8
5-bromo-2,3-dihydro-1H-pyrrolizin-1-one

: 1415034-35-3
ethyl 1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydropyrazolo[3,4-a]pyrrolizine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; ruphos; caesium carbonate / water; toluene / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

2: sodium; ethanol / 1 h / 20 °C

3: ethanol / 48 h / 80 °C

With ethanol; palladium diacetate; sodium; caesium carbonate; ruphos; In ethanol; water; toluene; 1: |Suzuki Coupling / 2: |Claisen Condensation;
DOI:10.1055/s-0032-1316703