N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

Base Information

Chemical Name:N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide
CAS No.:1111733-58-4
Molecular Formula:C₂₅H₂₂F₃NO₂
Molecular Weight:425.45
Hs Code.:

Synonyms:N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

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Chemical Property of N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

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Technology Process of N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

There total 9 articles about N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: N-(3,4-dimethylphenyl)-2-oxo-2-phenylacetamide

: 130365-87-6
2-[4-(trifluoromethyl)phenyl]ethyl bromide

N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide: 1111733-58-4
N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

Guidance literature:: With caesium carbonate; In toluene; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01900

Reference yield: 61.0%

: 1074-12-0
phenylglyoxal hydrate

: 1111734-75-8
3,4-dimethyl-N-(4-(trifluoromethyl)phenethyl)aniline

N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide: 1111733-58-4
N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

Guidance literature:: With pyridine; oxygen; copper(I) bromide; In toluene; at 60 ℃; for 12h; under 760.051 Torr;
DOI:10.1021/ol301130u

Reference yield: 40.0%

: 1111734-75-8
3,4-dimethyl-N-(4-(trifluoromethyl)phenethyl)aniline

: 122-78-1
phenylacetaldehyde

N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide: 1111733-58-4
N-(3,4-dimethylphenyl)-2-oxo-2-phenyl-N-(4-(trifluoromethyl)phenethyl)acetamide

Guidance literature:: With pyridine; oxygen; copper(I) bromide; In toluene; at 90 ℃; for 12h; under 760.051 Torr; Molecular sieve;
DOI:10.1002/anie.201105285