1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

Chemical Name:1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane
CAS No.:1242274-98-1
Molecular Formula:C₃₃H₅₄N₄O₇
Molecular Weight:618.814
Hs Code.:

Synonyms:1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of 1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

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Technology Process of 1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

There total 7 articles about 1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 51359-78-5
4-(bromomethyl)benzaldehyde

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 1242274-98-1
1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: With potassium carbonate; In acetonitrile; for 16h; Reflux;
DOI:10.1002/cmdc.201000124

Reference yield: 64.0%

: 623-27-8
terephthalaldehyde,

: 170161-27-0
1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 1242274-98-1
1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: terephthalaldehyde,; 1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.3390/molecules24081612

Reference yield:

: 1254176-43-6
C₃₃H₅₆N₄O₇

: 1242274-98-1
1-[4-(carboxaldehyde)phenylmethyl]-4,8,11-tris-(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: C₃₃H₅₆N₄O₇; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃;