benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate

Base Information

• Chemical Name: benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate
• CAS No.: 130413-05-7
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.295
• Mol file: 130413-05-7.mol

Synonyms:benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate

Chemical Property of benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate

There total 2 articles about benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-acetoxymethylphenol (6161-96-2) → benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate (130413-05-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 4.5h;

DOI:10.1021/jm990417j

Reference yield:

salicylic alcohol (90-01-7) → benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate (130413-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / BF₃*OEt₂ / diethyl ether / 4 h / 15 °C

2: 32 percent / PPTS

With boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In diethyl ether;

Reference yield: 94.0%

benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-, acetate (130413-05-7) → benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]- (130413-06-8)

Guidance literature:

With sodium hydroxide; In ethanol; at 18 ℃; for 1h;

upstream raw materials:

3,4-dihydro-2H-pyran

2-acetoxymethylphenol

salicylic alcohol

Downstream raw materials:

benzenemethanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-

carbamic acid, (2-chloroethyl)-2-hydroxy-1-benzyl ester

carbamic acid, (2-chloroethyl)-2-acetoxy-1-benzyl ester

carbamic acid, (2-chloroethyl)-2-[(tetrahydro-2H-pyran-2-yl)oxy]benzyl ester