(2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate

Base Information

• Chemical Name: (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate
• CAS No.: 159380-96-8
• Molecular Formula: C₁₇H₂₅NO₇S
• Molecular Weight: 387.454
• Mol file: 159380-96-8.mol

Synonyms:(2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate

Chemical Property of (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate

There total 3 articles about (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfanyl)propanoate (159380-94-6) → (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate (159380-96-8)

Guidance literature:

With potassium sulfate; potassium hydrogensulfate; potassium peroxomonosulfate; In methanol; for 4h; Ambient temperature;

Reference yield:

(-)-(2R)-2-amino-3-(2-hydroxyethylsulfanyl)propanoic acid (6367-98-2,19179-73-8) → (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate (159380-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tert-butyl alcohol, aq. NaOH / Ambient temperature

2: 1.) CsHCO₃ / 1.) MeOH, 2.) DMF, RT, 3 h

3: 93 percent / aq. KHSO₅ K₂SO₄, KHSO₄ (Oxone) / methanol / 4 h / Ambient temperature

With sodium hydroxide; potassium sulfate; potassium hydrogensulfate; potassium peroxomonosulfate; cesium bicarbonate; tert-butyl alcohol; In methanol;

Reference yield:

(R)-2-tert-Butoxycarbonylamino-3-(2-hydroxy-ethylsulfanyl)-propionic acid (245759-81-3) → (2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfonyl)propanoate (159380-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CsHCO₃ / 1.) MeOH, 2.) DMF, RT, 3 h

2: 93 percent / aq. KHSO₅ K₂SO₄, KHSO₄ (Oxone) / methanol / 4 h / Ambient temperature

With potassium sulfate; potassium hydrogensulfate; potassium peroxomonosulfate; cesium bicarbonate; In methanol;

upstream raw materials:

(2R)-(-)-benzyl 2-(tert-butoxycarbonylamino)-3-(2-hydroxyethylsulfanyl)propanoate

(-)-(2R)-2-amino-3-(2-hydroxyethylsulfanyl)propanoic acid

(R)-2-tert-Butoxycarbonylamino-3-(2-hydroxy-ethylsulfanyl)-propionic acid